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Chromium (VI) promotes EMT by regulating FLNA in BLCA
Author(s) -
Sheng Fei,
Chen KeXin,
Liu Jian,
Li JingXian,
Liang GeHong,
Xu Yong,
Du E,
Zhang ZhiHong
Publication year - 2021
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.23165
Subject(s) - chromium , flna , chemistry , environmental chemistry , environmental science , biochemistry , cell , cytoskeleton , filamin , organic chemistry
Hexavalent chromium (Cr (VI)), which is a recognized human carcinogen, is widely used in industrial production of raw materials. Evidence verifies that environmental contaminants in the urine can induce malignant transformation in the urinary bladder tract, and our data indicate that Cr (VI) could promote the proliferation and migration and inhibit the apoptosis of bladder cancer (BLCA) cells. However, the molecular mechanism remains ambiguous. We find that Filamin A (FLNA) is overexpressed in BLCA, and Cr (VI) promotes epithelial‐to‐mesenchymal transition by regulating FLNA in BLCA. Thus, inhibiting the expression of FLNA may be a prospective method for limiting the BLCA progression caused by Cr (VI) exposure.