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Anti‐apoptotic and pro‐survival effects of longan flower extracts on rat hearts with fructose‐induced metabolic syndrome
Author(s) -
Cheng ShiuMin,
Kumar V. Bharath,
Wu LiangYi,
Chang HsiaoChuan,
Kuo ChiaHua,
Wei LiShan,
Lin YuehMin,
Padma V. Vijaya,
Lee ShinDa,
Huang ChihYang
Publication year - 2021
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.23101
Subject(s) - fadd , apoptosis , tunel assay , fructose , metabolic syndrome , triglyceride , medicine , caspase , biology , endocrinology , pharmacology , biochemistry , chemistry , cholesterol , diabetes mellitus , programmed cell death
The aim of this study was to investigate the effects of longan flower (LF) water extract on cardiac apoptotic and survival pathways in rat models of fructose‐induced metabolic syndrome. The study findings revealed that the levels of glucose, insulin, triglyceride, and cholesterol and TUNEL‐positive apoptotic cells were significantly increased in the HF group compared with the control group; whereas, the levels were decreased in the HFLF group. The expressions of Fas, FADD, and activated caspases 8 and 3, as well as the expressions of Bax, Bak, Bax/Bcl‐2, Bak/Bcl‐xL, cytosolic cytochrome c, and activated caspases 9 and 3 were increased in the HF group were significantly reversed in HFLF administrated group. Furthermore, LF extract increased IGF‐1R, p‐PI3K, p‐Akt, Bcl‐2, and Bcl‐xL expression compared to HF group. Taken together, the present findings help identify LF as a potential cardioprotective agent that can be effectively used in treating fructose‐induced metabolic syndrome.