Premium
Therapeutic effects of rocket seeds ( Eruca sativa L .) against testicular toxicity and oxidative stress caused by silver nanoparticles injection in rats
Author(s) -
Altwaijry Najla,
ElMasry Thanaa A.,
Alotaibi Badriyah,
Tousson Ehab,
Saleh Asmaa
Publication year - 2020
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.22931
Subject(s) - oxidative stress , superoxide dismutase , luteinizing hormone , glutathione , chemistry , silver nanoparticle , thiobarbituric acid , testosterone (patch) , andrology , endocrinology , medicine , hormone , biochemistry , biology , lipid peroxidation , nanoparticle , enzyme , materials science , nanotechnology
Abstract Silver nanoparticles (AgNPs), one of the most well‐known nanomaterials, are regularly utilized in everyday consumer products. The present study aimed to investigate the testicular toxicity and oxidative stress by AgNPs and the therapeutic role of the rocket seeds ( Eruca sativa ) in treatments. Forty male Wistar rats were divided into four equivalent groups (group 1, control; group 2, rocket seeds extract [RS]; group 3, AgNPs; group 4, AgNPs+RS). Our results showed that AgNPs induced a significant decrease in serum total testosterone, FSH (follicle‐animating hormone), prolactin and LH (luteinizing hormone), testicular glutathione (GSH), superoxide dismutase (SOD), and glutathione S‐transferase (GST). In contrast, a significant increase in testicular DNA, injury, testicular thiobarbituric acid, proliferating cell nuclear antigen, and tumor necrosis factor‐α (TNFα) expressions after treatments with AgNPs when contrasted with the control group. Treatments of AgNPs with rocket seeds extract (AgNPs+RS) improved testicular functions and structure. Rocket seeds extract might offer benefits against the toxic nature of AgNPs.