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Andrographolide mitigates cardiac apoptosis to provide cardio‐protection in high‐fat‐diet‐induced obese mice
Author(s) -
Lin KuanHo,
Marthandam Asokan Shibu,
Kuo WeiWen,
Hsieh YouLiang,
Lii ChongKuei,
Viswanadha Vijayapadma,
Lin YiLin,
Wang Shulin,
Yang Caixian,
Huang ChihYang
Publication year - 2020
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.22906
Subject(s) - andrographolide , andrographis paniculata , apoptosis , medicine , endocrinology , metabolite , pharmacology , chemistry , biochemistry , pathology , alternative medicine
Excessive intake of high fat diet (HFD) and associated obese conditions are critical contributors of cardiac diseases . In this study, an active metabolite andrographolide from Andrographis paniculata was found to ameliorate HFD‐induced cardiac apoptosis. C57/BL6 mouse were grouped as control (n = 9), obese (n = 8), low dose (25 mg/kg/d) andrographolide treatment (n = 9), and high dose (50 mg/kg/d) andrographolide treatment (n = 9). The control group was provided with standard laboratory chow and the other groups were fed with HFD. Andrographolide was administered through oral gavage for 1 week. Histopathological analysis showed increase in apoptotic nuclei and considerable cardiac‐damages in the obese group signifying cardiac remodeling effects. Further, Western blot results showed increase in pro‐apoptotic proteins and decrease in the proteins of IGF‐1R‐survival signaling. However, feeding of andrographolide significantly reduced the cardiac effects of HFD. The results strongly suggest that andrographolide supplementation can be used for prevention and treatment of cardiovascular disease in obese patients.