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Mesoporous silica induces hippocampal neurons cell autophagy through AMPK/mTOR/P70S6K signaling pathway
Author(s) -
Zhang Na,
Zhi Xiaoyu,
Zhao Ji,
Wei Jinglin,
Li Jiangping,
Yang Huifang
Publication year - 2020
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.22854
Subject(s) - ampk , pi3k/akt/mtor pathway , autophagy , hippocampal formation , chemistry , microbiology and biotechnology , mesoporous silica , protein kinase a , amp activated protein kinase , mtorc2 , signal transduction , phosphorylation , sirolimus , mtorc1 , pharmacology , mesoporous material , neuroscience , biology , biochemistry , apoptosis , catalysis
Mesoporous silica is a drug carrier with strong targeting, large loading capacity, and easy modification of its surface while its toxicity draws increasing attention recently. In this study, we evaluated the impact of SBA‐15 nanomaterials on hippocampal neurons. We found that SBA‐15 induces oxidative damage to hippocampal neurons HT22, which further activates autophagy. Treatment with the mammalian target of rapamycin (mTOR) inhibitor AZD8055, the phosphorylation level of mTOR and P70S6K reduced and increased levels of p‐AMPK meaning that the adenosine‐activated protein kinase (AMPK)/mTOR/P70S6K pathway is involved in SBA‐15 induced autophagy of HT22. These results suggested that mesoporous silica material SBA‐15 might affect central nervous cells via oxidative stress activation of the AMPK/mTOR/P70S6K pathway, which provides a theoretical basis for safe administration of such materials in patients.