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Protective effects of galangin against H 2 O 2 ‐induced aging via the IGF‐1 signaling pathway in human dermal fibroblasts
Author(s) -
Wen SuYing,
Chen JiaYi,
Chen ChihJung,
Huang ChihYang,
Kuo WeiWen
Publication year - 2020
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.22847
Subject(s) - galangin , downregulation and upregulation , senescence , chemistry , signal transduction , pharmacology , microbiology and biotechnology , biochemistry , biology , antioxidant , flavonoid , kaempferol , gene
Galangin, a natural flavonol, has anti‐inflammatory and antioxidative potential. However, the cytoprotective effects of galangin against oxidative‐induced aging in human fibroblasts have not been well studied. IGF‐1 signaling pathway is associated with the control of aging and longevity in human. The goal of this study was to investigate the effects of galangin on human skin fibroblast HS68 cells under H 2 O 2 exposure to induce aging. In this study, we demonstrate that galangin could decrease the levels of pro‐inflammatory proteins and enhanced collagen formation through promoting the IGF‐1R pathway. Furthermore, aging markers such as senescence‐associated β‐galactosidase p53, p21 Cip1/WAF1 , and p16 INK4A were upregulated under H 2 O 2 exposure and galangin could reverse its effects. Taken together, these data indicated that anti‐inflammatory and antiaging activities of galangin may be mediated through the IGF‐1R signaling pathway. These findings may provide the evidence for galangin to develop as an antiwrinkle product on human skin.