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Barium chloride dose‐dependently induced heart and lung injury in Wistar rats
Author(s) -
Omole Joseph G.,
Alabi Quadri K.,
Aturamu Ayodeji,
Adefisayo Modinat A.,
Oluwayomi Oludare,
Dada Moses B.,
Ige Mokolade S.
Publication year - 2019
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.22831
Subject(s) - medicine , endocrinology , lactate dehydrogenase , lipid peroxidation , chemistry , lung , superoxide dismutase , oxidative stress , glutathione , biochemistry , enzyme
Barium (Ba) is one of the environmental pollutant metals that incite deleterious effects on human health. The present study investigated the effects of exposure to different doses of barium chloride (BaCl 2 ) on heart and lung of Wistar rats. Rats were exposed to BaCl 2 at 150, 300, and 600 mg/L for seven consecutive days. Results indicated that exposure to Ba caused heart and lung damage evidenced by significant increase in plasma lactate dehydrogenase and creatine kinase activities, total cholesterol, triglyceride, and low‐density lipoprotein‐cholesterol levels, while high‐density lipoprotein‐cholesterol level decreased when compared with control. Moreover, BaCl 2 significantly decreased superoxide dismutase, catalase, and acetylcholinesterase activities as well as glutathione level in heart and lung of the treated rats. Furthermore, the dose‐dependent increase in cardiac and lung lipid peroxidation, advanced oxidative protein product and nitric oxide levels were accompanied by marked increase in metallothionein in the BaCl 2 ‐treated rats. Administration of BaCl 2 altered hematological parameters and significantly increased concentrations of interleukin‐6 in the treated rats. Histology analysis showed significant alteration in the heart and lung tissues of Ba‐treated rats. In conclusion, BaCl 2 ‐induced heart and lung damages via disruption of antioxidant defense systems, and activation of inflammatory mediators and alteration in hematological parameters in rats.