Premium
Propamocarb exposure decreases the secretion of neurotransmitters and causes behavioral impairments in mice
Author(s) -
Zhang Yi,
Jin Cuiyuan,
Wang Xiaoyu,
Shen Manlu,
Zhou Jiajie,
Wu Sisheng,
Fu Zhengwei,
Jin Yuanxiang
Publication year - 2019
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.22653
Subject(s) - neurotoxicity , open field , tph2 , dopamine , elevated plus maze , serotonin , acute toxicity , behavioural despair test , toxicology , toxicity , biology , medicine , endocrinology , antidepressant , hippocampus , anxiety , psychiatry , serotonergic , receptor
Propamocarb (PM) is a type of fungicide, which is widely used in the greenhouse‐based production of vegetables and fruits globally. It has been considered to have generally low toxicity. However, the teratogenicity or neurotoxicity for mammals remains unclear. In this study, we aimed to explore its effect on the secretion of neurotransmitters and behavioral impairments. Male adult mice were exposed to 10 and 40 mg/L PM for 2 weeks (acute exposure) or 3 and 10 mg/L PM for 10 weeks (chronic exposure). It was observed that acute or chronic exposure to PM changed the levels of serotonin (5‐HT) and dopamine in the serum and colon and the transcription of TPH2 and DRD2 in the colons of mice. In addition, the locomotor test, the open field test, and the Morris water maze analysis also showed that acute exposure to PM caused behavioral impairments to some extent. The results obtained in the present study indicated that PM has the potential to induce neurotoxicity in animals.