Premium
Tributyltin reduces the levels of serum adiponectin and activity of AKT and induces metabolic syndrome in male mice
Author(s) -
Yan Haotian,
Guo Hao,
Cheng Dong,
Kou Ruirui,
Zhang Cuili,
Si Jiliang
Publication year - 2018
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.22562
Subject(s) - adiponectin , medicine , endocrinology , insulin resistance , tributyltin , leptin , metabolic syndrome , hyperlipidemia , protein kinase b , insulin , chemistry , biology , diabetes mellitus , apoptosis , obesity , biochemistry , organic chemistry
Tributyltin (TBT), a proven environmental obesogen, functions as a nanomolar agonist of the peroxisome proliferator activated receptor‐γ (PPARγ). However, the adverse effects of TBT on metabolism are incompletely understood. In this study, male ICR mice were administered TBT (5 and 50 μg·kg –1 ) by an intraperitoneal injection once every 3 days for 30 days from 28 days of age and bred for another 30 days after the last administration of TBT. We analyzed the effects of these exposures on the fat depot weights, serum lipid profile, serum leptin and adiponectin, hepatic lipid accumulation, and activity of AKT in the liver and skeletal muscle isolated from mice 8 mins after receiving an insulin injection. Pubertal exposure to TBTCl resulted in a higher body weight, increased epididymal and liver fat accumulation, hyperlipidemia, an elevated low‐density lipoprotein/high‐density lipoprotein ratio, serum adiponectin deficiency, worse glucose tolerance, and lower insulin‐dependent AKT phosphorylation in the liver and muscle in mice. These results showed that TBT exposure induced peripheral insulin resistance and metabolic syndrome in mice.