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Halloysite nanotubes‐induced Al accumulation and oxidative damage in liver of mice after 30‐day repeated oral administration
Author(s) -
Wang Xue,
Gong Jiachun,
Gui Zongxiang,
Hu Tingting,
Xu Xiaolong
Publication year - 2018
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.22543
Subject(s) - oral administration , toxicity , oxidative stress , in vivo , pharmacology , halloysite , chemistry , biocompatibility , endocrinology , medicine , biochemistry , biology , materials science , microbiology and biotechnology , organic chemistry , composite material
Halloysite (Al 2 Si 2 O 5 (OH) 4 · n H 2 O) nanotubes (HNTs) are natural clay materials and widely applied in many fields due to their natural hollow tubular structures. Many in vitro studies indicate that HNTs exhibit a high level of biocompatibility, however the in vivo toxicity of HNTs remains unclear. The objective of this study was to assess the hepatic toxicity of the purified HNTs in mice via oral route. The purified HNTs were orally administered to mice at 5, 50, and 300 mg/kg body weight (BW) every day for 30 days. Oral administration of HNTs stimulated the growth of the mice at the low dose (5 mg/kg BW) with no liver toxicity, but inhibited the growth of the mice at the middle (50 mg/kg BW) and high (300 mg/kg BW) doses. In addition, oral administration of HNTs at the high dose caused Al accumulation in the liver but had no marked effect on the Si content in the organ. The Al accumulation caused significant oxidative stress in the liver, which induced hepatic dysfunction and histopathologic changes. These findings demonstrated that Al accumulation‐induced oxidative stress played an important role in the oral HNTs‐caused liver injury.