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Adipose‐derived stem cells decrease cardiomyocyte damage induced by porphyromonas gingivalis endotoxin through suppressing hypertrophy, apoptosis, fibrosis, and MAPK markers
Author(s) -
Chen TungSheng,
Kuo ChiaHua,
Battsengel Sarnai,
Pan LungFa,
Day Cecilia Hsuan,
Shen ChiaYao,
Chung LiChin,
Padma V. Vijaya,
Yao ChenKai,
Lin YuehMin,
Huang ChihYang
Publication year - 2018
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.22536
Subject(s) - porphyromonas gingivalis , fibrosis , apoptosis , adipose tissue , stem cell , viability assay , cancer research , p38 mitogen activated protein kinases , mapk/erk pathway , muscle hypertrophy , microbiology and biotechnology , myocardial fibrosis , biology , pharmacology , chemistry , medicine , signal transduction , endocrinology , periodontitis , biochemistry
Heart failure is one of the complications related to periodontal disease. In addition to drugs or herbal medicines, stem cell therapy shows potential in the treatment of cardiomyopathy. This study investigates if stem cells exhibit beneficial effects on cardiomyocyte damage induced by porphyromonas gingivalis endotoxin (Pg‐LPS). From the experimental results we find that Pg‐LPS reduce cardiomyocyte viability via the activation of apoptosis, hypertrophy, fibrosis and MAPK signaling. Pg‐LPS damaged cardiomyocytes co‐cultured with adipose‐derived stem cells (ADSC) increases cardiomyocyte viability through suppressing the pathological markers described above. Further evidence implies that survival marker, IGF1, secreted from ADSC, may play an important role in the Pg‐LPS induced protective effect on cardiomyocyte damage.