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Cortactin is a prognostic marker for oral squamous cell carcinoma and its overexpression is involved in oral carcinogenesis
Author(s) -
Liu YuChing,
Ho HengChien,
Lee MiauRong,
Yeh ChungMin,
Tseng HsienChang,
Lin YungChang,
Chung JingGung
Publication year - 2017
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.22280
Subject(s) - cortactin , carcinogenesis , papilloma , pathology , immunohistochemistry , cancer research , biology , arecoline , oncogene , carcinoma , papillomatosis , cell , cancer , medicine , cell cycle , biochemistry , genetics , receptor , muscarinic acetylcholine receptor , cytoskeleton
ABSTRACT EMS1 (chromosome eleven, band q13, mammary tumor and squamous cell carcinoma‐associated gene 1) gene amplification and the concomitant cortactin overexpression have been reported to associate with poor prognosis and tumor metastasis. In this study, we examined cortactin expression by immunohistochemistry in human oral tumors and murine tongue tumors which were induced by the carcinogen 4‐nitroquinoline 1‐oxide (4‐NQO). The immunostaining results show over‐ to moderate expression of cortactin in 85% (104/122) of oral squamous cell carcinoma (OSCC) tissues and in all 15 leukoplakia tissues examined. Further, statistical analysis indicates that cortactin overexpression appears to be a predictor for shorter survival and poorer prognosis in OSCC patients. In an animal model, cortactin is shown to upregulate in infiltrating squamous cell carcinoma, papilloma, and epithelia with squamous hyperplasia, indicating that cortactin induction is an early event during oral carcinogenesis. It is suggested that cortactin expression is mediated in the progression of pre‐malignancy to papilloma, based on earlier cortactin induction in pre‐malignancy preceding cyclin D1 in papilloma. In conclusion, cortactin overexpression is frequently observed in human OSCC and mouse tongue tumors. Thus, cortactin may have an important role in the development of oral tumors in human and mice. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 799–812, 2017.