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Hispolon suppresses migration and invasion of human nasopharyngeal carcinoma cells by inhibiting the urokinase‐plasminogen activator through modulation of the Akt signaling pathway
Author(s) -
Ho HsinYu,
Ho YungChuan,
Hsieh MingJu,
Yang ShunFa,
Chuang ChunYi,
Lin ChiaoWen,
Hsin ChungHan
Publication year - 2017
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.22266
Subject(s) - protein kinase b , nasopharyngeal carcinoma , cancer research , signal transduction , apoptosis , cell growth , chemistry , phellinus linteus , biology , biochemistry , medicine , botany , mycelium , radiation therapy
Hispolon has been reported to possess antioxidant, antiinflammatory, and antitumor activities. However, the effect of hispolon on the metastasis of nasopharyngeal carcinoma (NPC) remains unclear. In this study, we investigated how the antimetastatic activity and relevant signaling pathways of hispolon affected three NPC cell lines. The results revealed that hispolon significantly reduced the migration and invasion of three NPC cells in a dose‐dependent manner from 0 to 50 µM. Hispolon also significantly inhibited the activity and expression of urokinase‐plasminogen activator (uPA) as well as the phosphorylation of Akt. Moreover, blocking the Akt pathway also enhanced the antimetastatic ability of hispolon in the NPC cells. In conclusion, hispolon inhibited uPA expression and NPC cell metastasis by downregulating Akt signal pathways; therefore, hispolon exerts beneficial effects in chemoprevention. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 645–655, 2017.