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Curcumin alleviated the toxic reaction of Rhizoma Paridis saponins in a 45‐day subchronic toxicological assessment of rats
Author(s) -
Man Shuli,
Li Jing,
Liu Jing,
Chai Hongyan,
Liu Zhen,
Wang Jiaming,
Gao Wenyuan
Publication year - 2016
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.22194
Subject(s) - curcumin , pharmacology , chemistry , glutathione , malondialdehyde , oxidative stress , curcuma , antioxidant , alanine transaminase , aspartate transaminase , alkaline phosphatase , toxicity , hepatoprotection , lipid peroxidation , biochemistry , traditional medicine , medicine , enzyme , organic chemistry
Rhizoma Paridis saponins (RPS), as steroid saponins, are the main components in Paris polyphylla . Curcumin (diferuloylmethane) is the most important component in the spice turmeric. In our previous research, RPS exhibited side effects such as nausea, vomiting, diarrhea, and so forth. Combination with curcumin not only alleviated the toxicity and gastric stimulus induced by RPS, but also improved the quality life of mice bearing tumor cells and enhanced their anticancer effect. This study evaluated subchronic toxicity of 45 th dietary of RPS and curcumin on histopathology, biochemistry, and antioxidant index. As a result, RPS‐treatment caused a slight liver injury (the elevation of serum AST, alkaline phosphatase (AKP), alanine transaminase (ALT), and gamma glutamyl transpeptidase (γ‐GT), histopathological changes in liver section), oxidative stress (the enhancement of reactive oxygen species (ROS), malondialdehyde (MDA), and 8‐hydroxy‐2‐deoxyguanosine (8‐OHdG), separation of thioredoxin (Trx) and thioredoxin‐interacting protein (TXNIP), but enhancement of heme oxygenase‐1 (HO‐1), glutathione S‐transferase (GST), and nuclear factor‐regulated factor 2 (Nrf2)), and inflammation (up‐regulation of cyclooxygenase‐2 (COX‐2), interleukin‐1β (IL‐1β), and nuclear factor kappaB (NF‐κB)). However, these changes were alleviated through co‐treatment with curcumin. In conclusion, our work provided useful data for further research and new drug exploration of RPS and curcumin. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1935–1943, 2016.