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Reproductive toxicity and histopathological changes induced by lambda‐cyhalothrin in male mice
Author(s) -
AlSarar Ali S.,
Abobakr Yasser,
Bayoumi Alaa E.,
Hussein Hamdy I.,
AlGhothemi Mousa
Publication year - 2014
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.21802
Subject(s) - cyhalothrin , reproductive toxicity , nephrotoxicity , toxicity , epididymis , seminal vesicle , sperm , pyrethroid , spleen , biology , andrology , spermatogenesis , median lethal dose , cypermethrin , testicle , adult male , toxicology , physiology , pharmacology , medicine , endocrinology , immunology , prostate , pesticide , cancer , agronomy
Lambda‐cyhalothrin (LCT) is a widely used broad‐spectrum pyrethroid insecticide. Oral LCT administration to adult male mice at 3 doses (0.2, 0.4, and 0.8 mg/kg/day) for 6 weeks caused a significant reduction in the weight of the seminal vesicles. The epididymal sperm count was lower in mice that received at the highest dose than in control mice. However, the proportions of live and motile spermatozoa were reduced at both the medium and the high doses compared with control mice. All doses induced an increase in the number of morphologically abnormal spermatozoa. Histopathological observations of the testes, liver, kidneys, and spleen showed dose‐related degenerative damage in LCT‐treated mice. The results indicate that LCT has reproductive toxicity, hepatotoxicity, nephrotoxicity, and splenotoxicity in male mice at the tested doses. © 2012 Wiley Periodicals, Inc. Environ Toxicol 29: 750–762, 2014.