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Immune dysfunction and liver damage of mice following exposure to lanthanoids
Author(s) -
Cheng Jie,
Cheng Zhe,
Hu Renping,
Cui Yaling,
Cai Jingwei,
Li Na,
Gui Suxing,
Sang Xuezi,
Sun Qingqing,
Wang Ling,
Hong Fashui
Publication year - 2014
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.20773
Subject(s) - medicine , endocrinology , immune system , toxicity , liver function , cd8 , lymphocyte , white blood cell , albumin , globulin , uric acid , bilirubin , biology , chemistry , immunology
In an effort to investigate the effects of exposure to lanthanoids (Ln) on the immune response and liver function, mice were orally exposed to LaCl 3 , CeCl 3 , and NdCl 3 at 2, 10, and 20 mg/kg doses for 30 days, respectively; lymphocyte counts, serum IgM level, hematological indices, biochemical parameters of liver functions, and histopathological changes in Ln 3+ ‐treated mice were assessed. Indeed, 20 mg/kg Ln 3+ significantly inhibited mice growth and reduced the counts of white blood cells, platelets, and reticulocyte in mice blood. Specifically, in these Ln 3+ ‐treated mice, CD3+, CD4+, CD8+, CD19+ and NK cells, and CD4+/CD8+ ratio as well as serum IgM level were decreased. Furthermore, liver function was disrupted, as evidenced by the increased alanine aminotransferase, total bilirubin, total bile acid and triglycerides, and the decreased glucose and ratio of albumin to globulin. The cytoarchitecture damage and fatty degeneration in liver caused by Ln 3+ at 20 mg/kg dose were also observed. Our findings showed that exposure to Ln affected the cell and humoral immunity and disturbed liver function in mice. In addition, Ce 3+ was found to exhibit higher toxicity than La 3+ and Nd 3+ . © 2011 Wiley Periodicals, Inc. Environ Toxicol 29: 64–73, 2014.