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Estrogen‐like response of perfluorooctyl iodide in male medaka ( Oryzias latipes ) based on hepatic vitellogenin induction
Author(s) -
Wang Yichen,
Zhou Qunfang,
Wang Chang,
Yin Nuoya,
Li Zhuona,
Liu Jiyan,
Jiang Guibin
Publication year - 2013
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.20751
Subject(s) - vitellogenin , oryzias , estrogen , estrogen receptor , biology , estrone , downregulation and upregulation , endocrine disruptor , medicine , endocrinology , in vivo , chemistry , gene , biochemistry , hormone , genetics , endocrine system , cancer , breast cancer
Using the in vivo male medaka model, we investigated the estrogen‐like response of perfluorooctyl iodide (PFOI) which is a potential source of perfluorinated carboxylic acids. Using real‐time quantitative polymerase chain reaction, the expression levels of related estrogenic genes including estrogenic receptor α (ERα), ERβ, vitellogenin I (VTG I), and VTG II in the livers of male medaka exposed to PFOI were analyzed. The results showed that PFOI upregulated the expression levels of the tested genes in a dose‐dependent manner. VTG protein levels increased in both dose‐ and time‐dependent manners due to PFOI exposure. The results suggested that PFOI is a potential estrogenic compound. © 2011 Wiley Periodicals, Inc. Environ Toxicol 28: 571–578, 2013.