Estrogen‐like response of perfluorooctyl iodide in male medaka ( Oryzias latipes ) based on hepatic vitellogenin induction | Zendy

Wang Yichen | Zendy; Zhou Qunfang | Zendy; Wang Chang | Zendy; Yin Nuoya | Zendy; Li Zhuona | Zendy; Liu Jiyan | Zendy; Jiang Guibin | Zendy

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Estrogen‐like response of perfluorooctyl iodide in male medaka ( Oryzias latipes ) based on hepatic vitellogenin induction

Author(s) -

Wang Yichen,

Zhou Qunfang,

Wang Chang,

Yin Nuoya,

Li Zhuona,

Liu Jiyan,

Jiang Guibin

Publication year - 2013

Publication title -

environmental toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.813

H-Index - 77

eISSN - 1522-7278

pISSN - 1520-4081

DOI - 10.1002/tox.20751

Subject(s) - vitellogenin , oryzias , estrogen , estrogen receptor , biology , estrone , downregulation and upregulation , endocrine disruptor , medicine , endocrinology , in vivo , chemistry , gene , biochemistry , hormone , genetics , endocrine system , cancer , breast cancer

Using the in vivo male medaka model, we investigated the estrogen‐like response of perfluorooctyl iodide (PFOI) which is a potential source of perfluorinated carboxylic acids. Using real‐time quantitative polymerase chain reaction, the expression levels of related estrogenic genes including estrogenic receptor α (ERα), ERβ, vitellogenin I (VTG I), and VTG II in the livers of male medaka exposed to PFOI were analyzed. The results showed that PFOI upregulated the expression levels of the tested genes in a dose‐dependent manner. VTG protein levels increased in both dose‐ and time‐dependent manners due to PFOI exposure. The results suggested that PFOI is a potential estrogenic compound. © 2011 Wiley Periodicals, Inc. Environ Toxicol 28: 571–578, 2013.

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