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Metiram‐induced nephrotoxicity in albino mice: Effect of licorice aqueous extract
Author(s) -
Sakr Saber,
ELKenawy Ayman,
ELSahra Doaa
Publication year - 2013
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.20728
Subject(s) - nephrotoxicity , proliferating cell nuclear antigen , blood urea nitrogen , kidney , creatinine , aqueous extract , toxicity , pharmacology , chemistry , antioxidant , urea , endocrinology , medicine , traditional medicine , biochemistry , cell growth
The present study was designed to estimate the effect of aqueous extract of licorice on metiram toxicity in mice. Treating mice with metiram at a dose level of [1/2] LD 50 daily for 3 weeks induced many histological changes in the kidney cortex. The renal tubules lost their characteristic appearance and their lining epithelial cells were degenerated. The glomeruli were atrophied and the renal blood vessels were congested. The intertubular spaces infiltrated by inflammatory leukocytic cells. Metiram caused an increase in proliferating cell nuclear antigen (PCNA) expression in nuclei of tubular epithelial cells. Metiram also caused marked elevation in serum creatinine and blood urea nitrogen. Treating animals with metiram and licorice aqueous extract led to an improvement, in both biochemical and histopathological alterations. These results proved that licorice had an ameliorative effect against kidney injury induced by metiram and this effect may be attributed to its antioxidant activity. © 2011 Wiley Periodicals, Inc. Environ Toxicol, 2013.