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Protective effects of melatonin in reduction of oxidative damage and immunosuppression induced by aflatoxin B 1 ‐contaminated diets in young chicks
Author(s) -
Sirajudeen M.,
Gopi Kandasamy,
Tyagi Jagbir Singh,
Moudgal Ram Phal,
Mohan Jag,
Singh Ram
Publication year - 2011
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.20539
Subject(s) - aflatoxin , catalase , superoxide dismutase , melatonin , lipid peroxidation , oxidative stress , broiler , toxicity , chemistry , biology , endocrinology , food science , biochemistry , organic chemistry
In the present study, the ability of aflatoxin B 1 (AFB 1 ) to induce endogenous oxidative damages and the possible ameliorating effects of dietary melatonin (MEL) were investigated. Newly hatched broiler chicks ( n = 240) were fed aflatoxin‐contaminated diets (0.5 or 1 mg kg −1 diet) with or without MEL (40 mg kg −1 bw) supplementation in diet for 40 days. AFB 1 resulted in a significant increase in lipid peroxidation (LPO) in the liver and erythrocytes accompanied with suppression of superoxide dismutase (SOD) and catalase (CAT) enzyme activities of erythrocytes. It also caused a significant reduction in levels of serum proteins and marked elevation in activities of serum transaminases. AFB 1 treatment also decreased both humoral and cell‐mediated immune responses in growing chicks. Simultaneous administration of MEL with AFB 1 resulted in an obvious improvement in all the tested parameters. Long‐term rather than short‐term administration of MEL was more effective in rendering protection against AFB 1 ‐induced toxicity. © 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 153–160, 2011.