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Apoptotic‐related protein changes induced by hexavalent chromium in mice liver
Author(s) -
Wang XiaoFeng,
Lou XiaoMing,
Shen Ying,
Xing MingLuan,
Xu LiHong
Publication year - 2010
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.20478
Subject(s) - hexavalent chromium , apoptosis , downregulation and upregulation , potassium dichromate , cytochrome c , cytochrome , chemistry , apoptosome , bcl 2 associated x protein , caspase 3 , biology , microbiology and biotechnology , programmed cell death , caspase , chromium , biochemistry , enzyme , gene , inorganic chemistry , organic chemistry
Although it has been reported that hexavalent chromium (Cr(VI)) could induce apoptosis in a variety of cell types, the molecular mechanisms underlying this process is still largely unknown. This study was undertaken to determine effects of single oral 0, 25, 50, and 100 mg/kg body weight doses of potassium dichromate on the expression level of p53, Bcl‐2, Bax, cytochrome c, and caspase‐3, which are vital regulators of apoptosis, in mice liver. The results showed that Cr(VI) could upregulate the protein expression of p53, Bax, cytochrome c, and caspase‐3 and downregulate the expression of Bcl‐2 in mice liver. All these results suggested that p53, Bcl‐2, Bax, cytochrome c, and caspase‐3 may be involved in the regulation of Cr(VI) induced apoptosis in vivo . © 2009 Wiley Periodicals, Inc. Environ Toxicol, 2010.