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Reproductive and developmental toxicity screening study of 2,4‐dinitrophenol in rats
Author(s) -
Takahashi Mika,
Sunaga Masao,
HirataKoizumi Mutsuko,
Hirose Akihiko,
Kamata Eiichi,
Ema Makoto
Publication year - 2009
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.20398
Subject(s) - reproductive toxicity , body weight , toxicity , lactation , developmental toxicity , reproduction , teratology , biology , zoology , physiology , mating , weight gain , toxicology , medicine , pregnancy , gestation , endocrinology , ecology , genetics
Rats were treated by gavage once daily with 2,4‐dinitrophenol (DNP) at 0 (control), 3, 10, or 30 mg/kg bw. Males were dosed for 46 days, beginning 14 days before mating, and females were dosed for 40–47 days, from 14 days before mating to day 3 of lactation. No deaths were observed in males and females of any group. A significant decrease in body weight gain and significant increase in liver weight were found in males and females at 30 mg/kg bw/day. The number of live pups on postnatal days (PNDs) 0 and 4, live birth index, and body weight of live male and female pups on PNDs 0 and 1 were significantly lowered at 30 mg/kg bw/day. External and internal examinations of pups revealed no increased incidence of malformations in DNP‐treated groups. On the basis of these findings, we concluded that DNP has general and reproductive/developmental toxicity, but not teratogenicity, under the present conditions. The NOAEL of DNP is considered to be 10 mg/kg bw/day in rats. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2009.