Inorganic arsenic induces necrosis of human CD34‐positive haematopoietic stem cells | Zendy

Vernhet Laurent | Zendy; Morzadec Claudie | Zendy; van Grevenynghe Julien | Zendy; Bareau Benoît | Zendy; Corolleur Michel | Zendy; Fest Thierry | Zendy; Fardel Olivier | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Inorganic arsenic induces necrosis of human CD34‐positive haematopoietic stem cells

Author(s) -

Vernhet Laurent,

Morzadec Claudie,

van Grevenynghe Julien,

Bareau Benoît,

Corolleur Michel,

Fest Thierry,

Fardel Olivier

Publication year - 2008

Publication title -

environmental toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.813

H-Index - 77

eISSN - 1522-7278

pISSN - 1520-4081

DOI - 10.1002/tox.20334

Subject(s) - haematopoiesis , cd34 , progenitor cell , stem cell , apoptosis , in vitro , biology , microbiology and biotechnology , arsenic , chemistry , biochemistry , organic chemistry

Inorganic arsenic is a major environmental contaminant known to exert immunosuppressive effects. In this study, we report toxicity of As 2 O 3 , a trivalent inorganic form, toward isolated human hematopoietic CD34+ progenitor cells. Our results demonstrate that low concentrations of As 2 O 3 (0.1–5 μM) inhibit in vitro proliferation of CD34+ cells and their differentiation into various hematological cell lineages. These effects were associated with the induction of a necrotic process independent of caspases and likely related to mitochondrial damage. We conclude that As 2 O 3 can impair in vitro human hematopoiesis by decreasing survival of CD34+ progenitor cells. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2008.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research