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Inorganic arsenic induces necrosis of human CD34‐positive haematopoietic stem cells
Author(s) -
Vernhet Laurent,
Morzadec Claudie,
van Grevenynghe Julien,
Bareau Benoît,
Corolleur Michel,
Fest Thierry,
Fardel Olivier
Publication year - 2008
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.20334
Subject(s) - haematopoiesis , cd34 , progenitor cell , stem cell , apoptosis , in vitro , biology , microbiology and biotechnology , arsenic , chemistry , biochemistry , organic chemistry
Inorganic arsenic is a major environmental contaminant known to exert immunosuppressive effects. In this study, we report toxicity of As 2 O 3 , a trivalent inorganic form, toward isolated human hematopoietic CD34+ progenitor cells. Our results demonstrate that low concentrations of As 2 O 3 (0.1–5 μM) inhibit in vitro proliferation of CD34+ cells and their differentiation into various hematological cell lineages. These effects were associated with the induction of a necrotic process independent of caspases and likely related to mitochondrial damage. We conclude that As 2 O 3 can impair in vitro human hematopoiesis by decreasing survival of CD34+ progenitor cells. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2008.