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Determining the mechanisms of toxic action of phenols to Tetrahymena pyriformis
Author(s) -
Ren S.
Publication year - 2002
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.10040
Subject(s) - phenols , electrophile , chemistry , tetrahymena pyriformis , quantitative structure–activity relationship , homo/lumo , organic chemistry , environmental chemistry , computational chemistry , stereochemistry , tetrahymena , molecule , biochemistry , catalysis
Phenols are environmentally important compounds that are widely used in agriculture and industry. Thus, phenols are of interest to environmental toxicologists, which has led to the development of several quantitative structure–activity relationship (QSAR) models. The most successful QSARs have been established for compounds having a common mechanism of toxic action (MOA). However, correctly determining the MOA of a compound is not easy. Discriminant analysis was used in this study to separate phenols by their MOAs. The working hypothesis of this study was that phenols with different MOAs lie in different regions in the response surface described by the ionization‐corrected hydrophobicity descriptor, log D, the electrophilicity descriptor, E LUMO , and the interaction between hydrophobicity and electrophilicity, D ∗ E LUMO . Results of discriminant analysis showed a total error rate of 15%. In addition, it was difficult to separate phenols that had a polar narcosis MOA from phenols that had a proelectrophile MOA. © 2002 Wiley Periodicals, Inc. Environ Toxicol 17: 119–127, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/tox.10040