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Acute toxicity, mutagenicity, and estrogenicity of bisphenol‐A and other bisphenols
Author(s) -
Chen MinYu,
Ike Michihiko,
Fujita Masanori
Publication year - 2002
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.10035
Subject(s) - daphnia magna , bisphenol a , toxicity , acute toxicity , chemistry , ec50 , bisphenol , yeast , toxicology , pharmacology , environmental chemistry , biochemistry , biology , organic chemistry , in vitro , epoxy
Although abundant data are available on the toxicity of bisphenol‐A (2,2‐bis (4‐hydroxydiphenyl)propane; BPA), little is known about the toxicities of the structurally similar compounds, namely bisphenols (BPs). A variety of BPs were examined for their acute toxicity against Daphnia magna , mutagenicity, and estrogenic activity using the Daphtoxkit (Creasel Ltd.), the umu test system, and the yeast two‐hybrid system, respectively, in comparison with BPA. BPA was moderately toxic to D. magna (48‐h EC 50 was 10 mg/l) according to the current U.S. EPA acute toxicity evaluation standard, and it was weakly estrogenic with 5 orders of magnitude lower activity than that of the natural estrogen 17β‐estradiol in the yeast screen, while no mutagenicity was observed. All seven BPs tested here showed moderate to slight acute toxicity, no mutagenicity, and weak estrogenic activity as well as BPA. Some of the BPs showed considerably higher estrogenic activity than BPA, and others exhibited much lower activity. Among the tested BPs, two compounds, i.e., bisphenol‐S (bis(4‐hydroxydiphenyl)sulfone) and bis(4‐hydroxyphenyl)sulfide, have never been reported for their estrogenic activity previously. © 2002 by Wiley Periodicals, Inc. Environ Toxicol 17: 80–86, 2002