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Protective effects of Sasa veitchii extract on acute ethanol‐induced hepatotoxicity in mice
Author(s) -
Yoshioka Hiroki,
Tominaga Sarah,
Nishikawa Mai,
Ichimaru Yoshimi,
Maeda Tohru,
ogaki Tsunemasa,
Fujii Hirohisa,
Nakao Makoto
Publication year - 2020
Publication title -
traditional and kampo medicine
Language(s) - English
Resource type - Journals
ISSN - 2053-4515
DOI - 10.1002/tkm2.1245
Subject(s) - ethanol , aldehyde dehydrogenase , alcohol , chemistry , alcohol dehydrogenase , liver injury , lipid peroxidation , alanine aminotransferase , oxidative stress , pharmacology , alcoholic liver disease , biochemistry , medicine , enzyme , cirrhosis
Aim High alcohol consumption leads to alcohol‐related disease. The aim of this study was to explore the effects of Sasa veitchii extract (SE) on ethanol‐induced liver injury. Methods Of four groups of 7‐week‐old male mice (control, SE, ethanol, and SE + ethanol groups), SE and SE + ethanol groups were orally treated with SE once a day for 3 days. Twenty‐four hours after the last administration, the SE + ethanol and ethanol groups were intraperitoneally injected with ethanol (2 g/kg). The mice in each group were euthanized 24 h after ethanol administration, and blood and livers were collected. Results Histopathological examination of the livers of ethanol‐treated mice revealed a depletion of glycogen. Ethanol injection resulted in high plasma levels of alanine aminotransferase and aspartate aminotransferase and high levels of hepatic lipid peroxidation and inflammatory cytokines. Pretreatment with SE reversed all these changes in SE + ethanol mice compared to that in the ethanol group. Moreover, SE injection increased the hepatic protein levels of aldehyde dehydrogenase 2. Conclusion Our results show that SE protected the mice against acute ethanol‐induced hepatic injury by modulating oxidative stress and ethanol metabolism, and hence, could be explored for treatment of alcohol‐related disease.