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Effect of hangebyakujutsutemmato on pregabalin‐induced dizziness in a rat model of neuropathic pain
Author(s) -
Watanabe Kunitaro,
Moriyama Kumi,
Tokumine Joho,
Yorozu Tomoko
Publication year - 2019
Publication title -
traditional and kampo medicine
Language(s) - English
Resource type - Journals
ISSN - 2053-4515
DOI - 10.1002/tkm2.1218
Subject(s) - pregabalin , medicine , neuropathic pain , anesthesia
Aim This study investigated the efficacy of hangebyakujutsutemmato (HBT) in alleviating disturbances of equilibrium using a rat pregabalin model of neuropathic pain with dizziness. Pregabalin is effective for treating neuropathic pain, but some patients cannot tolerate continued treatment owing to dizziness resulting from pregabalin, especially shortly after beginning treatment. HBT is a Japanese kampo medicine that is used to treat dizziness. Methods Rats with chronic constriction injury of the sciatic nerve (Bennett and Xie model) underwent the beam balance test to evaluate their sense of equilibrium. The animals were divided into four groups, as follows: pregabalin (50 mg/kg) + HBT (1 g/kg; PH), n = 8; pregabalin (50 mg/kg; P), n = 8; HBT (1 g/kg; H), n = 8; and water (N), n = 8. Pregabalin and HBT treatments were initiated 9 days following injury. Results On postoperative day 10 (POD10), the day after starting drug treatment, there was a significant difference in the crossing time between PH and P ( P < 0.01). The crossing time in group P recovered to a level similar to the other groups on POD16. Conclusion HBT alleviated the disturbance of equilibrium resulting from pregabalin in a rat model of neuropathic pain. This suggests that HBT may also alleviate dizziness and/or accelerate recovery from dizziness due to pregabalin treatment in humans.