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Therapeutic effects of shikonin on skin lesions in mouse models of allergic dermatitis and wound
Author(s) -
Kadoyama Keiichi,
Takenokuchi Mariko,
Matsuura Kenji,
Shichiri Hiroaki,
Watanabe Aimi,
Yamaguchi Hirotsugu,
Takahashi Hisashi,
TakanoOhmuro Hiromi,
Taniguchi Taizo
Publication year - 2019
Publication title -
traditional and kampo medicine
Language(s) - English
Resource type - Journals
ISSN - 2053-4515
DOI - 10.1002/tkm2.1216
Subject(s) - atopic dermatitis , allergic dermatitis , medicine , dermatology , wound healing , allergic contact dermatitis , allergy , therapeutic effect , betamethasone , dorsum , immunology , surgery , anatomy
Aim The aim of this study was to examine the beneficial effects of shikonin on skin lesions in mouse models of allergic dermatitis and wound. Methods Mouse models of allergic dermatitis and wound were generated by spreading an allergic‐inducing reagent on the dorsal skin and earflaps, and by punching the dorsal skin, respectively. The effects of shikonin on allergic dermatitis was evaluated on frequency of scratching, clinical severity of dermatitis and immunohistochemistry. The effect of shikonin on wound healing compared with steroid was evaluated by the size of the wound area. Results Shikonin treatment not only improved allergic dermatitis, but also prevented the onset of allergic dermatitis. Furthermore, shikonin promoted wound healing in a mouse model of skin wound. In contrast, steroid (betamethasone) treatment, which is often applied to treat allergic dermatitis, delayed wound healing in the mouse model of allergic dermatitis. Conclusion Shikonin can be used as a new therapeutic agent for the treatment of allergic dermatitis including atopic dermatitis.