Premium
Antimicrobial effects of shin'iseihaito in vitro and clinical background factors of S taphylococcus aureus infection
Author(s) -
Minami Masaaki,
Konishi Toru,
Sakakibara Ryoko,
Imura Taichi,
Watanabe Mika,
Morita Hideo,
Kanemaki Naoto,
Makino Toshiaki
Publication year - 2017
Publication title -
traditional and kampo medicine
Language(s) - English
Resource type - Journals
ISSN - 2053-4515
DOI - 10.1002/tkm2.1073
Subject(s) - staphylococcus aureus , medicine , antimicrobial , levofloxacin , broth microdilution , sputum , microbiology and biotechnology , antibiotics , pneumonia , pathogenic bacteria , tuberculosis , minimum inhibitory concentration , bacteria , biology , pathology , genetics
Aim Staphylococcus aureus is a pathogenic bacterium that causes various serious diseases such as sinusitis and pneumonia. Recently, emergence of drug‐resistant bacteria, including methicillin‐resistant S. aureus ( MRSA ), has reduced therapeutic outcome. Shin'iseihaito ( SSHT ; X inyiqingfeitang in C hinese) is a formula of kampo medicine and traditional C hinese medicine for the treatment of upper respiratory tract infectious diseases. To determine the point of differential diagnosis for choosing this formula for clinical applications, we examined the relationship between the clinical background factors of S. aureus infection and the antimicrobial effect of SSHT extract against S. aureus in vitro . Methods A total of 203 S. aureus samples were collected from patients, and the relationships between the clinical characteristics, antibiotic‐susceptibility patterns, and SSHT were investigated using disk diffusion and microdilution methods. Results The antimicrobial effect of SSHT extract against both methicillin‐sensitive and ‐resistant S. aureus was 57.1% and 67.2%, respectively ( P = n.s.). Significant differences were found, however, in SSHT sensitivity with respect to patient background, including gender, age (<10 years and >10 years), specimen isolation site, and treatment department. Furthermore, significant differences in SSHT sensitivity were also noted between levofloxacin‐resistant and ‐susceptible S. aureus . Conclusion SSHT is a possible anti‐infective agent against S. aureus , and its effect was correlated with gender (women), age (elderly), specimen isolation sites (sputum), respiratory medicine department, and levofloxacin‐resistant bacteria.