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Quick and easy preparation method for Kampo formula decoctions (part 4): IPCD method for rhubarb and aconite root
Author(s) -
Fueki Tsukasa,
Chiba Koki,
Makino Toshiaki,
Matsuoka Takanori,
Satou Tadaaki,
Koike Kazuo,
Tanaka Koichiro,
Sumino Megumi,
Namiki Takao
Publication year - 2016
Publication title -
traditional and kampo medicine
Language(s) - English
Resource type - Journals
ISSN - 2053-4515
DOI - 10.1002/tkm2.1057
Subject(s) - decoction , traditional medicine , rhizome , chemistry , chromatography , bupleurum , traditional chinese medicine , medicine , alternative medicine , pathology
Aim The immersing powdered crude drugs (IPCD) method has been developed as a quick, easy and high‐yielding method for preparing decoctions. Given that the extraction process is different from the conventional decoction method, the safety of this method should be carefully examined. In the present study, the amounts of the diester alkaloids of aconite root, the tuberous root of Aconitum carmichaeli , and sennoside A of rhubarb, the rhizome of Rheum palmatum , were determined in the IPCD immersion. Both of these compounds have strong physiological activities and have been suggested to be decomposed during the decoction process. Methods The amounts of marker compounds in the IPCD immersion prepared from processed or unprocessed aconite root or rhubarb were measured and compared with those prepared using the conventional decoction method. Results The amount of sennoside A extracted with the IPCD method was 1.1‐fold increased compared with that from the conventional method. No diester alkaloids were detected in the IPCD immersion prepared from processed aconite root, whereas for unprocessed aconite root, the amount of diester alkaloids extracted from the IPCD immersion was 8.8‐fold higher than that from the conventional decoctions. Conclusion The IPCD method can be safely used on rhubarb or well‐processed aconite root under the same conditions as other less‐powerful crude drugs, whereas precautions are required for unprocessed aconite root.