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Prophylactic repetitive shakuyakukanzoto treatment inhibits paclitaxel‐induced mechanical allodynia in mice via peripheral effects
Author(s) -
Andoh Tsugunobu,
Kobayashi Nao,
Kuraishi Yasushi
Publication year - 2016
Publication title -
traditional and kampo medicine
Language(s) - English
Resource type - Journals
ISSN - 2053-4515
DOI - 10.1002/tkm2.1039
Subject(s) - paclitaxel , allodynia , medicine , peripheral , peripheral neuropathy , peripheral nerve injury , anesthesia , neuropathic pain , pharmacology , hyperalgesia , nociception , chemotherapy , surgery , sciatic nerve , endocrinology , receptor , diabetes mellitus
Aim Peripheral neuropathy is the major dose‐limiting side‐effect of paclitaxel. We examined whether the traditional herbal formulation shakuyakukanzoto ( SKT ) inhibited paclitaxel‐induced mechanical allodynia and peripheral nerve activity in mice, and identified the site at which SKT exerted its effects. Methods The mice received i.p. injections of paclitaxel. SKT was given orally once daily from the day after the injection of paclitaxel. Mechanical allodynia in the hind paw was evaluated using a von F rey filament. The activity of the saphenous nerve was recorded electrophysiologically, using a bipolar electrode. Results A single i.p. injection of paclitaxel induced mechanical allodynia, which peaked on day 14. Prophylactic repetitive SKT treatment attenuated paclitaxel‐induced mechanical allodynia. The paclitaxel‐treated mice had increased spontaneous and von F rey filament‐induced firing of the saphenous nerve. These increased nerve firings were inhibited by repetitive SKT treatment. Conclusion Prophylactic repetitive SKT treatment inhibited paclitaxel‐induced mechanical allodynia and peripheral nerve activity. Moreover, SKT inhibited paclitaxel‐induced spontaneous nerve firing, and thus, SKT may be effective for spontaneous pain (including also numbness). Thus, SKT prevents neuropathic dysesthesia through a peripheral action.