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Analysis of licorice‐induced pseudoaldosteronism in the J apanese A dverse D rug E vent R eport database
Author(s) -
Kato Yamato,
Umetsu Ryogo,
Hosoya Naoki,
Ueda Natsumi,
Abe Junko,
Nakayama Yoko,
Motooka Yumi,
Kinosada Yasutomi,
Oyama Masayoshi,
Nakamura Mitsuhiro
Publication year - 2016
Publication title -
traditional and kampo medicine
Language(s) - English
Resource type - Journals
ISSN - 2053-4515
DOI - 10.1002/tkm2.1029
Subject(s) - medicine , adverse drug event , adverse effect , odds ratio , incidence (geometry) , database , drug , pharmacology , computer science , physics , optics
Aim We analyzed the association of age, sex, and dosage with licorice‐associated pseudoaldosteronism using spontaneous adverse event reports. Methods Pseudoaldosteronism incidence data from 2004 to 2013 were obtained from the J apanese A dverse D rug E vent R eport ( JADER ) database. These reports were analyzed using a reporting odds ratio ( ROR ). Medical D ictionary for R egulatory A ctivities‐preferred terms were used to identify pseudoaldosteronism. Results Pseudoaldosteronism was reported frequently in female patients aged >50 years. ROR of pseudoaldosteronism were calculated and stratified by licorice dosage. ROR (95% CI ) for doses <2.5, 2.5–4.9, and ≥5.0 g were 20.9 (15.1–28.8), 26.1 (15.1–45.0), and 147.3 (150.3–206.0), respectively. Conclusion Despite the limitations of spontaneous reporting, licorice dosage may be associated with pseudoaldosteronism. Considering the causality restraint of the current analysis, further epidemiological studies are recommended.