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Human mesenchymal stem cells as a stable source of VEGF‐producing cells
Author(s) -
Kagiwada Harumi,
Yashiki Tetsuya,
Ohshima Akira,
Tadokoro Mika,
Nagaya Noritoshi,
Ohgushi Hajime
Publication year - 2008
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.79
Subject(s) - mesenchymal stem cell , angiogenesis , vascular endothelial growth factor , vegf receptors , regulator , microbiology and biotechnology , in vivo , stem cell , bone marrow , vascular endothelial growth factor a , biology , cancer research , immunology , chemistry , gene , biochemistry
Abstract Vascular endothelial growth factor (VEGF) is a positive regulator and plays a crucial role in angiogenesis. We demonstrate that VEGF was highly expressed in cultures of human bone marrow‐derived mesenchymal stem cells (hMSCs) and the high expression level was maintained during prolonged culture periods (checked up to passage 10). We also confirmed that in vivo hMSCs engrafted into immunodeficient mice could survive and secreted human VEGF. These findings suggest that implantation of hMSCs is a practical means as a source of VEGF production and might be effective in neoangiogenesis. Copyright © 2008 John Wiley & Sons, Ltd.