Premium
Skeletal tissue engineering using silk biomaterials
Author(s) -
MacIntosh Ana C.,
Kearns Victoria R.,
Crawford Aileen,
Hatton Paul V.
Publication year - 2008
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.68
Subject(s) - silk , sericin , bombyx mori , tissue engineering , fibroin , biocompatible material , scaffold , coating , materials science , biomedical engineering , spider silk , nanotechnology , polymer science , chemistry , composite material , engineering , biochemistry , gene
Silks have been proposed as potential scaffold materials for tissue engineering, mainly because of their physical properties. They are stable at physiological temperatures, flexible and resist tensile and compressive forces. Bombyx mori (silkworm) cocoon silk has been used as a suture material for over a century, and has proved to be biocompatible once the immunogenic sericin coating is removed. Spider silks have a similar structure to silkworm silk but do not have a sericin coating. This paper provides a general overview on the use of silk protein in biomaterials, with a focus on skeletal tissue engineering. Copyright © 2008 John Wiley & Sons, Ltd.