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Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts)
Author(s) -
Bessa P. C.,
Casal M.,
Reis R. L.
Publication year - 2008
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.63
Subject(s) - bone morphogenetic protein , tissue engineering , bone morphogenetic protein 2 , cartilage , bone morphogenetic protein 10 , bone morphogenetic protein 7 , microbiology and biotechnology , biology , biomedical engineering , engineering , anatomy , in vitro , biochemistry , gene
Discovered in 1965, bone morphogenetic proteins (BMPs) are a group of cytokines from the transforming growth factor‐β (TGFβ) superfamily with significant roles in bone and cartilage formation. BMPs are used as powerful osteoinductive components of diverse tissue‐engineering products for the healing of bone. Several BMPs with different physiological roles have been identified in humans. The purpose of this review is to cover the biological function of the main members of BMP family, the latest research on BMPs signalling pathways and advances in the production of recombinant BMPs for tissue engineering purposes. Copyright © 2008 John Wiley & Sons, Ltd.