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Experimental therapies for repair of the central nervous system: stem cells and tissue engineering
Author(s) -
Forraz N,
Wright KE,
Jurga M,
McGuckin CP
Publication year - 2013
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.552
Subject(s) - tissue engineering , regeneration (biology) , mesenchymal stem cell , neural stem cell , neuroscience , central nervous system , stem cell , neural tissue engineering , regenerative medicine , medicine , cell therapy , biomedical engineering , pathology , biology , microbiology and biotechnology
Several stem cell‐based therapeutic tools are currently being investigated for the regeneration of central nervous system (CNS) injuries. This review focuses on innovative approaches for CNS tissue repair via the use of implantable cellular devices. These devices are supported by biopharmaceuticals and conventional physiotherapy for the restoration of lost neuronal circuits and CNS function. This paper further reviews new and promising tools currently in pre‐clinical and clinical tests for the treatment of CNS diseases where substantial loss of cellular and extracellular components of neural tissue has occurred such as stroke, encephalopathy and traumatic neural injuries. We also discuss selected 3D bioscaffolds co‐cultured with clinically applicable human mesenchymal stem cells. Recent advances in neural tissue engineering and stem cell differentiation methods have shown promise for their clinical application in treating yet incurable CNS deficits. Copyright © 2012 John Wiley & Sons, Ltd.