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In vivo imaging and evaluation of different biomatrices for improvement of stem cell survival
Author(s) -
Cao Feng,
Sadrzadeh Rafie Amir H.,
Abilez Oscar J.,
Wang Haichang,
Blundo Jennifer T.,
Pruitt Beth,
Zarins Christopher,
Wu Joseph C.
Publication year - 2007
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.55
Subject(s) - stem cell , matrigel , in vivo , biomedical engineering , tissue engineering , chemistry , regenerative medicine , cell , microbiology and biotechnology , medicine , biology , biochemistry
Therapeutic effects from injection of stem cells are often hampered by acute donor cell death as well as migration away from damaged areas. This is likely due to the fact that injected cells do not have the physical and biochemical cues for ordered engrafment. Here we evaluate 3 common biomatrices (Matrigel, Collagen I, Purmatrix) that has the potential of providing suitable scaffolds needed to enhance stem cell survival. The longitudinal fate of transplanted stem cells was monitored by reporter imaging techniques. Copyright © 2008 John Wiley & Sons, Ltd.