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Flux of selected body fluid constituents and benzylpenicillin in polyacrylamide hydrogel (PAAG)
Author(s) -
Brahm J.,
Lessel R.,
Ditlev S.,
Schmidt R.
Publication year - 2012
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.485
Subject(s) - chemistry , permeation , urea , inulin , polyacrylamide , self healing hydrogels , benzylpenicillin , chromatography , polyacrylamide gel electrophoresis , membrane , peg ratio , food science , polymer chemistry , biochemistry , penicillin , finance , economics , antibiotics , enzyme
The polyacrylamide hydrogel (PAAG) Aquamid® (Contura International A/S Soeborg, Denmark) is one of the new macromolecules that are used as implants and tissue fillers in reconstruction and aesthetic surgery. This study showed, by means of radioactive isotope methods, that PAAG can exchange both physiological and non‐physiological constituents very efficiently with the surrounding medium. The efflux ( J , mole/(cm 2 × s), 25 °C, pH 7.2) of water (4.4 × 10 −5 ), chloride (2.4 × 10 −7 ), urea (1.0 × 10 −9 ), and glucose (1.1 × 10 −9 ) was 3‐40x greater than in human red blood cells. PAAG was also accessible to sucrose, inulin, and benzylpenicillin that could not permeate biological cell membranes. The conclusion of the study is that the hydrogel structure created no significant barrier to the exchange of solvent and solutes with the surrounding medium. Copyright © 2011 John Wiley & Sons, Ltd.