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In vitro platforms for tissue engineering: implications for basic research and clinical translation
Author(s) -
Rouwkema Jeroen,
Gibbs Susan,
Lutolf Matthias P.,
Martin Ivan,
VunjakNovakovic Gordana,
Malda Jos
Publication year - 2011
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.414
Subject(s) - translation (biology) , in vitro , tissue engineering , biomedical engineering , biochemical engineering , computer science , computational biology , chemistry , engineering , biology , biochemistry , messenger rna , gene
Clinical translation of engineered tissues into regenerative medicine applications, and the effort to reduce the use of animals for the screening of drugs and other compounds, result in an increasing demand for human tissues engineered in vitro for implantation, in vitro screening systems and basic research. Further development and optimization of in vitro models for quantitative studies of biophysical stimulation and mass transport in engineered tissues is seen as one of the high research priorities. A recent international symposium held in The Netherlands discussed the state of the art and key challenges in the development of bioreactor platforms and microscale technologies. Here we summarize the current status and future development of in vitro tissue models, based on the findings presented at this symposium. Copyright © 2011 John Wiley & Sons, Ltd.