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The advances in nerve tissue engineering: From fabrication of nerve conduit to in vivo nerve regeneration assays
Author(s) -
Jahromi Maliheh,
Razavi Shahnaz,
Bakhtiari Abbas
Publication year - 2019
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.2945
Subject(s) - regeneration (biology) , nerve guidance conduit , peripheral nerve , peripheral nerve injury , medicine , nerve injury , tissue engineering , sciatic nerve , electrical conduit , epineurial repair , in vivo , biomedical engineering , surgery , anatomy , biology , microbiology and biotechnology , engineering , mechanical engineering
Abstract Peripheral nerve damage is a common clinical complication of traumatic injury occurring after accident, tumorous outgrowth, or surgical side effects. Although the new methods and biomaterials have been improved recently, regeneration of peripheral nerve gaps is still a challenge. These injuries affect the quality of life of the patients negatively. In the recent years, many efforts have been made to develop innovative nerve tissue engineering approaches aiming to improve peripheral nerve treatment following nerve injuries. Herein, we will not only outline what we know about the peripheral nerve regeneration but also offer our insight regarding the types of nerve conduits, their fabrication process, and factors associated with conduits as well as types of animal and nerve models for evaluating conduit function. Finally, nerve regeneration in a rat sciatic nerve injury model by nerve conduits has been considered, and the main aspects that may affect the preclinical outcome have been discussed.