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Nanostructured fibrin agarose hydrogel as a novel haemostatic agent
Author(s) -
CamposCuerva Rafael,
FernándezMuñoz Beatriz,
Farfán López Francisco,
Pereira Arenas Sheila,
SantosGonzález Mónica,
LopezNavas Luis,
Alaminos Miguel,
Campos Antonio,
Muntané Jordi,
CepedaFranco Carmen,
GómezBravo Miguel Ángel
Publication year - 2019
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.2831
Subject(s) - fibrin , medicine , hemostasis , hemostatic agent , coagulation , hemostatics , surgery , inflammation , fibrin tissue adhesive , agarose , fibrin glue , blood loss , chemistry , immunology , chromatography
Blood loss remains a major concern during surgery and can increase the morbidity of the intervention. The use of topical haemostatic agents to overcome this issue therefore becomes necessary. Fibrin sealants are promising haemostatic agents due to their capacity to promote coagulation, but their effectiveness and applicability need to be improved. We have compared the haemostatic efficacy of a novel nanostructured fibrin‐agarose hydrogel patch, with (c‐NFAH) or without cells (a‐NFAH), against two commercially available haemostatic agents in a rat model of hepatic resection. Hepatic resections were performed by making short or long incisions (mild or severe model, respectively), and haemostatic agents were applied to evaluate time to haemostasis, presence of haematoma, post‐operative adhesions to adjacent tissues, and inflammation factors. We found a significantly higher haemostatic success rate (time to haemostasis) with a‐NFAH than with other commercial haemostatic agents. Furthermore, other relevant outcomes investigated were also improved in the a‐NFAH group, including no presence of haematoma, lower adhesions, and lower grades of haemorrhage, inflammation, and necrosis in histological analysis. Overall, these findings identify a‐NFAH as a promising haemostatic agent in liver resection and likely in a range of surgical procedures.