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Octacalcium phosphate collagen composite facilitates bone regeneration of large mandibular bone defect in humans
Author(s) -
Kawai Tadashi,
Suzuki Osamu,
Matsui Keiko,
Tanuma Yuji,
Takahashi Tetsu,
Kamakura Shinji
Publication year - 2017
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.2110
Subject(s) - dental alveolus , octacalcium phosphate , regeneration (biology) , chemistry , dentistry , mandible (arthropod mouthpart) , pathology , anatomy , medicine , phosphate , microbiology and biotechnology , biology , botany , organic chemistry , genus
Recently it was reported that the implantation of octacalcium phosphate (OCP) and collagen composite (OCP–collagen) was effective at promoting bone healing in small bone defects after cystectomy in humans. In addition, OCP–collagen promoted bone regeneration in a critical‐sized bone defect of a rodent or canine model. In this study, OCP–collagen was implanted into a human mandibular bone defect with a longer axis of approximately 40 mm, which was diagnosed as a residual cyst with apical periodontitis. The amount of OCP–collagen implanted was about five times greater than the amounts implanted in previous clinical cases. Postoperative wound healing was satisfactory and no infection or allergic reactions occurred. The OCP–collagen‐treated lesion was gradually filled with radio‐opaque figures, and the alveolar region occupied the whole of the bone defect 12 months after implantation. This study suggests that OCP–collagen could be a useful bone substitute material for repairing large bone defects in humans that might not heal spontaneously. Copyright © 2015 John Wiley & Sons, Ltd.