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A building‐block approach to 3D printing a multichannel, organ‐regenerative scaffold
Author(s) -
Wang Xiaohong,
Rijff Boaz Lloyd,
Khang Gilson
Publication year - 2017
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.2038
Subject(s) - scaffold , fused deposition modeling , rapid prototyping , plga , extrusion , nozzle , 3d printing , biomedical engineering , regenerative medicine , tissue engineering , polymer , materials science , deposition (geology) , glycolic acid , computer science , nanotechnology , mechanical engineering , chemistry , composite material , lactic acid , engineering , paleontology , biochemistry , sediment , biology , nanoparticle , cell , genetics , bacteria
Multichannel scaffolds, formed by rapid prototyping technologies, retain a high potential for regenerative medicine and the manufacture of complex organs. This study aims to optimize several parameters for producing poly(lactic‐co‐glycolic acid) (PLGA) scaffolds by a low‐temperature, deposition manufacturing, three‐dimensional printing (3DP, or rapid prototyping) system. Concentration of the synthetic polymer solution, nozzle speed and extrusion rate were analysed and discussed. Polymer solution with a concentration of 12% w/v was determined as optimal for formation; large deviation of this figure failed to maintain the desired structure. The extrusion rate was also modified for better construct quality. Finally, several solid organ scaffolds, such as the liver, with proper wall thickness and intact contour were printed. This study gives basic instruction to design and fabricate scaffolds with de novo material systems, particularly by showing the approximation of variables for manufacturing multichannel PLGA scaffolds. Copyright © 2015 John Wiley & Sons, Ltd.