Premium
Sustained‐release of naproxen sodium from electrospun‐aligned PLLA–PCL scaffolds
Author(s) -
Lui Yuan Siang,
Lewis Mark P.,
Loo Say Chye Joachim
Publication year - 2017
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.2000
Subject(s) - polycaprolactone , scaffold , tendon , electrospinning , regeneration (biology) , chemistry , naproxen , in vivo , biomedical engineering , adhesion , solvent , tissue engineering , chemical engineering , polymer , surgery , biochemistry , organic chemistry , microbiology and biotechnology , medicine , alternative medicine , engineering , pathology , biology
Spontaneous tendon healing may result in reduced tissue functionality. In view of this, tissue engineering (TE) emerges as a promising approach in promoting proper tendon regeneration. However, unfavourable post‐surgical adhesion formations restrict adequate tendon healing through the TE approach. Naproxen sodium (NPS), a non‐steroidal anti‐inflammatory drug (NSAID), has been demonstrated to prevent adhesions by inhibiting the inflammatory response. Therefore, in this study, various factors, such as polymer composition, i.e. different poly‐ l ‐lactic acid (PLLA):polycaprolactone (PCL) ratios, and percentage of water:hexafluoroisopropanol (HFIP; as co‐solvent) ratios, were investigated to understand how these can influence the release of NPS from electrospun scaffolds. By adjusting the amount of water as the co‐solvent, NPS could be released sustainably for as long as 2 weeks. Scaffold breaking strength was also enhanced with the addition of water as the co‐solvent. This NPS‐loaded scaffold showed no significant cytotoxicity, and L929 murine fibroblasts cultured on the scaffolds were able to proliferate and align along the fibre orientation. These scaffolds with desirable tendon TE characteristics would be promising candidates in achieving better tendon regeneration in vivo . Copyright © 2015 John Wiley & Sons, Ltd.