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Engineering tissues, organs and cells
Author(s) -
Atala Anthony
Publication year - 2007
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.18
Subject(s) - regenerative medicine , stem cell , economic shortage , embryonic stem cell , induced pluripotent stem cell , tissue engineering , transplantation , population , cell therapy , progenitor cell , biology , medicine , bioinformatics , microbiology and biotechnology , biomedical engineering , surgery , linguistics , philosophy , biochemistry , environmental health , government (linguistics) , gene
Patients suffering from diseased and injured organs may be treated with transplanted organs; however, there is a severe shortage of donor organs that is worsening yearly, given the ageing population. In the field of regenerative medicine and tissue engineering, scientists apply the principles of cell transplantation, materials science and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Therapeutic cloning, where the nucleus from a donor cell is transferred into an enucleated oocyte in order to extract pluripotent embryonic stem cells, offers a potentially limitless source of cells for tissue engineering applications. The stem cell field is also advancing rapidly, opening new options for therapy, including the use of amniotic and placental fetal stem cells. This review covers recent advances that have occurred in regenerative medicine and describes applications of these technologies using chemical compounds that may offer novel therapies for patients with end‐stage organ failure. Copyright © 2007 John Wiley & Sons, Ltd.