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Animal models for meniscus repair and regeneration
Author(s) -
Deponti Daniela,
Giancamillo Alessia Di,
Scotti Celeste,
Peretti Giuseppe M.,
Martin Ivan
Publication year - 2015
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.1760
Subject(s) - regeneration (biology) , meniscus , medial meniscus , biomedical engineering , computer science , engineering , biology , medicine , mathematics , microbiology and biotechnology , pathology , osteoarthritis , geometry , incidence (geometry) , alternative medicine
The meniscus plays an important role in knee function and mechanics. Meniscal lesions, however, are common phenomena and this tissue is not able to achieve spontaneous successful repair, particularly in the inner avascular zone. Several animal models have been studied and proposed for testing different reparative approaches, as well as for studying regenerative methods aiming to restore the original shape and function of this structure. This review summarizes the gross anatomy, function, ultrastructure and biochemical composition of the knee meniscus in several animal models in comparison with the human meniscus. The relevance of the models is discussed from the point of view of basic research as well as of clinical translation for meniscal repair, substitution and regeneration. Finally, the advantages and disadvantages of each model for various research directions are critically discussed. Copyright © 2013 John Wiley & Sons, Ltd.