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Synthesis and characterization of poly(glycerol‐co‐sebacate‐co‐ ε ‐caprolactone) elastomers
Author(s) -
Aydin H. M.,
Salimi K.,
Yilmaz M.,
Turk M.,
Rzayev Z. M. O.,
Pişkin E.
Publication year - 2016
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.1759
Subject(s) - elastomer , differential scanning calorimetry , materials science , glass transition , fourier transform infrared spectroscopy , dynamic mechanical analysis , polymer chemistry , caprolactone , chemical engineering , amorphous solid , polymer , biocompatibility , composite material , chemistry , polymerization , organic chemistry , physics , metallurgy , thermodynamics , engineering
Abstract In this study, poly(glycerol‐co‐sebacate‐co‐ ε ‐caprolactone) (PGSCL) elastomers were synthesized for the first time from the respective monomers. The structural analysis of PGSCL elastomers by nuclear magnetic resonance ( 1 H‐NMR) and Fourier transform infrared spectroscopy (FTIR) revealed that the elastomers have a high number of hydrogen bonds and crosslinks. X‐ray diffraction (XRD) and thermal analysis indicated an amorphous state. Differential scanning calorimetry (DSC) analysis showed that the elastomers has a glass transition temperature ( T g ) of –36.96°C. The Young's modulus and compression strength values were calculated as 46.08 MPa and 3.192 MPa, respectively. Calculations based on acid number and end groups analysis revealed a number average molecular weight of 148.15 kDa. Even though the foaming studies conducted by using supercritical CO 2 resulted in a porous structure; the obtained morphology tended to disappear after 48 h, leaving small cracks on the surface. This phenomenon was interpreted as an indication of self‐healing due to the high number of hydrogen bonds. The PGSCL elastomers synthesized in this study are flexible, robust to compression forces and have self‐healing capacity. Thanks to good biocompatibility and poor cell‐adhesion properties, the elastomers may find diverse applications where a postoperative adhesion barrier is required. Copyright © 2013 John Wiley & Sons, Ltd.