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PEG hydrogel degradation and the role of the surrounding tissue environment
Author(s) -
Reid Branden,
Gibson Matthew,
Singh Anirudha,
Taube Janis,
Furlong Cecilia,
Murcia Melissa,
Elisseeff Jennifer
Publication year - 2015
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.1688
Subject(s) - self healing hydrogels , peg ratio , ethylene glycol , degradation (telecommunications) , kinetics , chemistry , in vivo , tissue engineering , biophysics , chemical engineering , biomedical engineering , computer science , polymer chemistry , biology , organic chemistry , engineering , microbiology and biotechnology , telecommunications , physics , finance , quantum mechanics , economics
Poly(ethylene glycol) (PEG)‐based hydrogels are extensively used in a variety of biomedical applications, due to ease of synthesis and tissue‐like properties. Recently there have been varied reports regarding PEG hydrogel's degradation kinetics and in vivo host response. In particular, these studies suggest that the surrounding tissue environment could play a critical role in defining the inflammatory response and degradation kinetics of PEG implants. In the present study we demonstrated a potential mechanism of PEG hydrogel degradation, and in addition we show potential evidence of the role of the surrounding tissue environment on producing variable inflammatory responses. Copyright © 2013 John Wiley & Sons, Ltd.