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Development of functional biomaterials with micro‐ and nanoscale technologies for tissue engineering and drug delivery applications
Author(s) -
Bae Hojae,
Chu Hunghao,
Edalat Faramarz,
Cha Jae Min,
Sant Shilpa,
Kashyap Aditya,
Ahari Amir F.,
Kwon Cheong Hoon,
Nichol Jason W.,
Manoucheri Sam,
Zamanian Behnam,
Wang Yadong,
Khademhosseini Ali
Publication year - 2014
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.1494
Subject(s) - nanotechnology , drug delivery , tissue engineering , materials science , biomedical engineering , engineering
Micro‐ and nanotechnologies have emerged as potentially effective fabrication tools for addressing the challenges faced in tissue engineering and drug delivery. The ability to control and manipulate polymeric biomaterials at the micron and nanometre scale with these fabrication techniques has allowed for the creation of controlled cellular environments, engineering of functional tissues and development of better drug delivery systems. In tissue engineering, micro‐ and nanotechnologies have enabled the recapitulation of the micro‐ and nanoscale detail of the cell's environment through controlling the surface chemistry and topography of materials, generating 3D cellular scaffolds and regulating cell–cell interactions. Furthermore, these technologies have led to advances in high‐throughput screening (HTS), enabling rapid and efficient discovery of a library of materials and screening of drugs that induce cell‐specific responses. In drug delivery, controlling the size and geometry of drug carriers with micro‐ and nanotechnologies have allowed for the modulation of parametres such as bioavailability, pharmacodynamics and cell‐specific targeting. In this review, we introduce recent developments in micro‐ and nanoscale engineering of polymeric biomaterials, with an emphasis on lithographic techniques, and present an overview of their applications in tissue engineering, HTS and drug delivery. Copyright © 2012 John Wiley & Sons, Ltd.