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Gelatin cryogels crosslinked with oxidized dextran and containing freshly formed hydroxyapatite as potential bone tissue‐engineering scaffolds
Author(s) -
Inci Ilyas,
Kirsebom Harald,
Galaev Igor Yu,
Mattiasson Bo,
Piskin Erhan
Publication year - 2013
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.1464
Subject(s) - gelatin , dextran , elastic modulus , chemical engineering , tissue engineering , chemistry , materials science , aqueous solution , load bearing , aqueous medium , biomedical engineering , composite material , chromatography , organic chemistry , medicine , engineering
Gelatin‐based cryogels were prepared by using a novel crosslinker, oxidized dextran, which was synthesized and used in the study. The cryogels were also loaded with freshly formed hydroxyapatite (HA) particles. These cryogels are opaque, spongy and highly elastic and have a pore structure with large interconnected pores. They swell about 500% in aqueous media and within a few minutes reach their final swollen forms. The elastic moduli of HA‐containing cryogels were 18.5 ± 3.0 kPa, which is suitable for non‐load‐bearing bone tissue‐engineering (TE) applications, especially for the craniofacial area. Copyright © 2012 John Wiley & Sons, Ltd.