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Bisphosphonate determination using 1 H‐NMR spectroscopy for biomedical applications
Author(s) -
Chou J.,
Shimmon R.,
BenNissan B.
Publication year - 2009
Publication title -
journal of tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 72
eISSN - 1932-7005
pISSN - 1932-6254
DOI - 10.1002/term.142
Subject(s) - bisphosphonate , nuclear magnetic resonance spectroscopy , spectroscopy , chemistry , osteoporosis , analytical chemistry (journal) , nuclear magnetic resonance , chromatography , organic chemistry , physics , medicine , quantum mechanics , endocrinology
Bisphosphonate is known to be a very active drug in the treatment of osteoporosis and bone regeneration. A new method has been developed, utilizing nuclear magnetic resonance spectroscopy to identify and measure the amount of bisphosphonate in solution. A standard reference with similar functional group to that of the bisphosphonate was chosen and applied in the experimentation. The results showed that the use of nuclear magnetic resonance spectroscopy ( 1 H‐NMR) in determining the solvent residues of various pharmaceutical drugs has proved to be effective. Unlike chromatography, it is possible to use a universal reference standard as an internal standard assayed by quantitative NMR. Using the same theory, this method is capable of both identifying and quantifying the bisphosphonate in various solutions. This paper is the first publication showing this unique measurement method, which can be used in a range of pharmaceutical and biomedical applications. Copyright © 2008 John Wiley & Sons, Ltd.